L-Ergothioneine is a highly effective antioxidant naturally contained within the cellular make-up of the human body - because of modern diets and lifestyle, we have included this ingredient into our Pro-Age Marine Collagen Boost Night Cream and Advanced Vitamin C Serum based on leading research into this amazing ingredient:
Ultraviolet irradiation is one of the most important environmental factors in the development of a number of skin conditions, ranging from photo-ageing to cancer.
UVA/B rays penetrate into the skin, reach cells and are absorbed by proteins, lipids, and nuclear/mitochondrial DNA, causing a cascade of oxidative events that can result in progressive deterioration of cellular structure and function.
Mitochondria are responsible for producing approximately 90% of the cellular energy in the process of oxidative phosphorylation where electrons are transferred to oxygen - generating significant reactive oxygen species (ROS).
Mitochondria can counteract the production of ROS with antioxidants but some do escape, causing damage to mitochondrial DNA as well as proteins and lipids.
Mitochondria contain their own DNA (mtDNA), which is distinct from nuclear DNA and more susceptible to damage. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues during the process of ageing.
Mutations arise due to the close proximity to the inner membrane where reactive oxygen species are continually produced in the electron transport chain.
Photoaged skin is characterised by increased mutations in the mitochondrial genome, occurring more frequently with increased sun exposure.
L-Ergothioneine (EGT) is an unusual sulphur-containing derivative of an amino acid, histidine.
L-Ergothioneine is an integral component of the cellular antioxidant defence system. It scavenges hydroxyl and peroxynitrite radicals as well as the superoxide anion radical and singlet oxygen.
It has been demonstrated that EGT is a more powerful antioxidant than either coenzyme Q(10) or idebenone due to its relatively greater efficiency in directly scavenging free radicals and in protecting cells from UV-induced reactive oxygen species.